We are in the process of changing the way we perceive the world, the ways in which we interact with it and how we experience it. What we cannot foresee is, how will utilizing these ‘new realities’ – Virtual, Augmented and Mixed Realities – change us? How will the plasticity of our brains be impacted? Will this be the first time in human history that we actively and wittingly shape our brain’s evolution, with no real idea of how to control or guide the process, or what to do if and when it derails? Do we find ourselves in an epoch signaling an era of enlightenment or are we willfully limiting our mental capabilities? Will our powers of investigative thought, selection and creation still be fit for purpose in 50 years’ time, or will we rely entirely on computer-generated material? This panel of experiential designers and Other Reality specialists debates the topic.